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phenobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Lively alkylating metabolites.Barbiturates never impair standard hepatic purpose but are revealed to induce liver microsomal enzymes, So rising and/